![]() Going up a floor will remove one heart container and one passive item.Taking a hit from Mom's Hand brings Isaac to the starting room of a floor.Teleportation through resurrection by means of items like the Ankh is possible but dangerous since most resurrection items revive Isaac with very low health.Cursed Eye also works as a method of teleportation, but can come with the downside of unwanted teleportation.0 - The Fool, IX - The Hermit, and XVIII - The Moon are all viable teleportation cards. Booster Pack has a high chance to produce a card that can teleport Isaac since it spawns 5 random cards. Isaac only needs a starting item that produces a tarot card on pickup, such as Magic 8 Ball or Starter Deck.Even without powerful items or synergies, the challenge of Mega Satan (or any other boss) can be skipped by teleporting out of the room.The Wafer is an extremely useful item to receive in this challenge as well.Finally, size-decreasing items, such as Pluto or items that block bullets, such as Trinity Shield will drastically reduce the difficulty of most of Mega Satan's attacks. Having Gnawed Leaf and something that can do damage while not moving, such as Daddy Longlegs, Dead Bird, or Smart Fly, can basically guarantee an eventual win.Isaac also can heal from Mega Satan's rock waves and mini-bosses spawned by him which spawn ignited Bombs, Troll Bombs or Mega Troll Bombs. They also do plentiful damage to enemies and can open closed doors. Fetus, and Epic Fetus) combined is game breaking since as long as he gets caught by his explosions, he can heal indefinitely. Since Isaac will have at least 10 Red Heart containers from the start, Pyromaniac and items that grant exploding shots ( Ipecac, Dr.Resetting is a perfectly good way to ensure good items. Try to get some really powerful few-item synergies.While treasure rooms are disabled in this challenge, bosses will still offer a reward upon defeating them. ![]() However, no bosses need to be defeated to progress - teleporting out of boss rooms can make the challenge much easier. If Mega Satan and Satan can be defeated, the rest of the challenge becomes significantly easier. Starting with a random selection of items, and starting on the Mega Satan boss fight makes this challenge very difficult at first.
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